Regulation of Smad activities
نویسندگان
چکیده
منابع مشابه
Regulation of Smad Activity
binding by the ternary Smad–FAST complex. Smad3 can bers are a group of secreted polypeptides that regulate replace Smad2 in this complex and at the Mix.2 element a diverse array of developmental and biological pro-can activate transcription (Yeo et al., 1999), whereas at the cesses. Disruption of the ligands or of components of goosecoid promoter Smad3 blocks activation (Labbé et their signali...
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Elastin is crucial to pulmonary function, yet it appears in the pulmonary vasculature and interstitium late in gestation in large mammals and postnatally in rodents (1). Deletion of the ELN gene in mice produces obstructive arterial disease (2, 3) and disrupts terminal airway branching as well as alveogenesis (4); moreover, several forms of elastic tissue disease collectively known as cutis lax...
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Regulator of G protein signaling (RGS) proteins are united into a family by the presence of the homologous RGS domain that binds the subunits of heterotrimeric G proteins and accelerates their GTPase activity. A member of this family, RGS3 regulates the signaling mediated by Gq and Gi proteins by binding the corresponding G subunits. Here we show that RGS3 interacts with the novel partners Smad...
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TGF-β family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads. Nevertheless, TGF-β family proteins induce highly complex programs of gene expression responses that are extensively regulated, and depend on the physiological context of the cells. R...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
سال: 2006
ISSN: 0167-4781
DOI: 10.1016/j.bbaexp.2006.11.001